abstract：:In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, t...

journal_title：BMC medicine

authors： St Laurent G,Vyatkin Y,Kapranov P

更新日期：2014-06-12 00:00:00

abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...

journal_title：BMC medicine

authors： Lundin KE

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:Diarrhea is a leading cause of morbidity and mortality among children under five years of age. The Lives Saved Tool (LiST) is a model used to calculate deaths averted or lives saved by past interventions and for the purposes of program planning when costly and time consuming impact studies are not possible. ...

journal_title：BMC medicine

authors： Fischer Walker CL,Walker N

更新日期：2014-04-29 00:00:00

abstract：:Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and e...

journal_title：BMC medicine

authors： Brick T,Peters MJ

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...

journal_title：BMC medicine

authors： Tol WA,Komproe IH,Jordans MJ,Ndayisaba A,Ntamutumba P,Sipsma H,Smallegange ES,Macy RD,de Jong JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter u...

journal_title：BMC medicine

authors： Qiu S,Cai X,Chen X,Yang B,Sun Z

更新日期：2014-02-27 00:00:00

abstract：:This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...

journal_title：BMC medicine

authors： BioMed Central.

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:The United States Preventive Services Task Force (USPSTF) recommends screening adults for depression in primary care settings when staff-assisted depression management programs are available. This recommendation, however, is based on evidence from depression management programs conducted with patients alread...

journal_title：BMC medicine

authors： Thombs BD,Ziegelstein RC,Roseman M,Kloda LA,Ioannidis JP

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...

journal_title：BMC medicine

authors： Ellard DR,Thorogood M,Underwood M,Seale C,Taylor SJ

更新日期：2014-01-03 00:00:00

abstract：BACKGROUND:Over the last 100 years, several persistent misconceptions or 'false beliefs' have built up around allergen immunotherapy and its use in allergic rhinitis. This is perhaps because enthusiastic physicians administered complex allergen extracts to a diverse population of patients suffering from heterogeneous a...

journal_title：BMC medicine

authors： Calderón MA,Frankland AW,Demoly P

更新日期：2013-12-05 00:00:00

abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...

journal_title：BMC medicine

authors： Sabin CA

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Most UK medical schools use aptitude tests during student selection, but large-scale studies of predictive validity are rare. This study assesses the United Kingdom Clinical Aptitude Test (UKCAT), and its four sub-scales, along with measures of educational attainment, individual and contextual socio-economic...

journal_title：BMC medicine

authors： McManus IC,Dewberry C,Nicholson S,Dowell JS

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...

journal_title：BMC medicine

authors： Usher AK,Stockley RA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs. METHODS:A nested case?control study was co...

journal_title：BMC medicine

authors： Bellis JR,Kirkham JJ,Thiesen S,Conroy EJ,Bracken LE,Mannix HL,Bird KA,Duncan JC,Peak M,Turner MA,Smyth RL,Nunn AJ,Pirmohamed M

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:Australia was one of the first countries to introduce a publicly funded national human papillomavirus (HPV) vaccination program that commenced in April 2007, using the quadrivalent HPV vaccine targeting 12- to 13-year-old girls on an ongoing basis. Two-year catch-up programs were offered to 14- to 17- year-o...

journal_title：BMC medicine

authors： Gertig DM,Brotherton JM,Budd AC,Drennan K,Chappell G,Saville AM

更新日期：2013-10-22 00:00:00

abstract：BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...

journal_title：BMC medicine

authors： Strand E,Pedersen ER,Svingen GF,Schartum-Hansen H,Rebnord EW,Bjørndal B,Seifert R,Bohov P,Meyer K,Hiltunen JK,Nordrehaug JE,Nilsen DW,Berge RK,Nygård O

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and neonatal care. METHODS:This trial tested the hypothesis that teams of health care providers, administ...

journal_title：BMC medicine

authors： Pasha O,McClure EM,Wright LL,Saleem S,Goudar SS,Chomba E,Patel A,Esamai F,Garces A,Althabe F,Kodkany B,Mabeya H,Manasyan A,Carlo WA,Derman RJ,Hibberd PL,Liechty EK,Krebs N,Hambidge KM,Buekens P,Moore J,Jobe AH,

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...

journal_title：BMC medicine

authors： Higginson IJ,Koffman J,Hopkins P,Prentice W,Burman R,Leonard S,Rumble C,Noble J,Dampier O,Bernal W,Hall S,Morgan M,Shipman C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone (AVN), other) in patients undergoing primary total hip arthroplasty (THA). METHODS:We used prospec...

journal_title：BMC medicine

authors： Singh JA,Lewallen DG

更新日期：2013-09-24 00:00:00

abstract：BACKGROUND:We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to ...

journal_title：BMC medicine

authors： Berk M,Williams LJ,Jacka FN,O'Neil A,Pasco JA,Moylan S,Allen NB,Stuart AL,Hayley AC,Byrne ML,Maes M

更新日期：2013-09-12 00:00:00

abstract：:The launch of the 5th version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) has sparked a debate about the current approach to psychiatric classification. The most basic and enduring problem of the DSM is that its classifications are heterogeneous clinical descriptions rather than valid diagnose...

journal_title：BMC medicine

authors： Wardenaar KJ,de Jonge P

更新日期：2013-09-12 00:00:00

abstract：:Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of t...

journal_title：BMC medicine

authors： Castiblanco J,Arcos-Burgos M,Anaya JM

更新日期：2013-09-04 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake. METHODS:We followed-up 5,505 h...

journal_title：BMC medicine

authors： Gea A,Beunza JJ,Estruch R,Sánchez-Villegas A,Salas-Salvadó J,Buil-Cosiales P,Gómez-Gracia E,Covas MI,Corella D,Fiol M,Arós F,Lapetra J,Lamuela-Raventós RM,Wärnberg J,Pintó X,Serra-Majem L,Martínez-González MA,PREDIMED G

更新日期：2013-08-30 00:00:00

abstract：BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...

journal_title：BMC medicine

authors： Nakamura T,Matsuo T,Fukuda T,Yamato S,Yamaguchi K,Kinoshita I,Matsuzaki T,Nishiura Y,Nagasato K,Narita-Masuda T,Nakamura H,Satoh K,Sasaki H,Sakai H,Kawakami A

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-α inhibitors are increasingly being used in inflammatory bowel disease (IBD). Because this chronic intestinal disorder often affects women of fertile age, it is essential to assess the effect of biologics on pregnancy outcome. METHODS:We performed a systematic review of the Engli...

journal_title：BMC medicine

authors： Nielsen OH,Loftus EV Jr,Jess T

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:All rigorous primary cardiovascular disease (CVD) prevention guidelines recommend absolute CVD risk scores to identify high- and low-risk patients, but laboratory testing can be impractical in low- and middle-income countries. The purpose of this study was to compare the ranking performance of a simple, non-...

journal_title：BMC medicine

authors： Gaziano TA,Pandya A,Steyn K,Levitt N,Mollentze W,Joubert G,Walsh CM,Motala AA,Kruger A,Schutte AE,Naidoo DP,Prakaschandra DR,Laubscher R

更新日期：2013-07-24 00:00:00

abstract：:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...

journal_title：BMC medicine

authors： Caldas C

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:The cost-effectiveness of universal rotavirus (RV) vaccination is controversial in developed countries. As a result, RV vaccination programs do not currently exist in most European countries. Hospitalization is the main driver of RV disease costs, and prematurity, low birth weight (LBW) and underlying medica...

journal_title：BMC medicine

authors： Bruijning-Verhagen P,Mangen MJ,Felderhof M,Hartwig NG,van Houten M,Winkel L,de Waal WJ,Bonten MJ

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:The mind-body nexus has been a topic of growing interest. Further data are however required to understand the specific relationship between mood and anxiety disorders and individual physical health conditions, and to verify whether these psychiatric disorders are linked to overall medical burden. METHODS:Th...

journal_title：BMC medicine

authors： Sanna L,Stuart AL,Pasco JA,Kotowicz MA,Berk M,Girardi P,Brennan SL,Williams LJ

更新日期：2013-04-24 00:00:00

abstract：:Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lac...

journal_title：BMC medicine

authors： Jacob ST,Lim M,Banura P,Bhagwanjee S,Bion J,Cheng AC,Cohen H,Farrar J,Gove S,Hopewell P,Moore CC,Roth C,West TE

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies do not account for the extra work required to repurpose data for uses other than direct clinical car...

journal_title：BMC medicine

authors： Morrison C,Jones M,Jones R,Vuylsteke A

更新日期：2013-04-10 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...

journal_title：BMC medicine

authors： Ramagopalan SV,Goldacre R,Skingsley A,Conlon C,Goldacre MJ

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of randomized controlled trials (RCTs) with multiple arms. METHODS:The literature in the MEDLINE databa...

journal_title：BMC medicine

authors： Baron G,Perrodeau E,Boutron I,Ravaud P

更新日期：2013-03-27 00:00:00

abstract：:The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscit...

journal_title：BMC medicine

authors： Myburgh J,Finfer S

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early d...

journal_title：BMC medicine

authors： Rohrmann S,Overvad K,Bueno-de-Mesquita HB,Jakobsen MU,Egeberg R,Tjønneland A,Nailler L,Boutron-Ruault MC,Clavel-Chapelon F,Krogh V,Palli D,Panico S,Tumino R,Ricceri F,Bergmann MM,Boeing H,Li K,Kaaks R,Khaw KT,Wareha

更新日期：2013-03-07 00:00:00

abstract：BACKGROUND:In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the relationship between these two paradigms. This work is designed to establish the foundations for a c...

journal_title：BMC medicine

authors： Altamirano-Bustamante MM,Altamirano-Bustamante NF,Lifshitz A,Mora-Magaña I,de Hoyos A,Avila-Osorio MT,Quintana-Vargas S,Aguirre JA,Méndez J,Murata C,Nava-Diosdado R,Martínez-González O,Calleja E,Vargas R,Mejía-Arangure JM,C

更新日期：2013-02-15 00:00:00